Delayed Sympathetic Dependence in the Spared Nerve Injury (SNI) Model of Neuropathic Pain
نویسندگان
چکیده
منابع مشابه
Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain
BACKGROUND Clinical and experimental studies of neuropathic pain support the hypothesis that a functional coupling between postganglionic sympathetic efferent and sensory afferent fibers contributes to the pain. We investigated whether neuropathic pain-related behavior in the spared nerve injury (SNI) rat model is dependent on the sympathetic nervous system. RESULTS Permanent chemical sympath...
متن کاملExplorer Delayed sympathetic dependence in the spared nerve injury ( SNI ) model of neuropathic pain
Background: Clinical and experimental studies of neuropathic pain support the hypothesis that a functional coupling between postganglionic sympathetic efferent and sensory afferent fibers contributes to the pain. We investigated whether neuropathic pain-related behavior in the spared nerve injury (SNI) rat model is dependent on the sympathetic nervous system. Results: Permanent chemical sympath...
متن کاملThe Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice
Peripheral neuropathic pain is a severe chronic pain condition which may result from trauma to sensory nerves in the peripheral nervous system. The spared nerve injury (SNI) model induces symptoms of neuropathic pain such as mechanical allodynia i.e. pain due to tactile stimuli that do not normally provoke a painful response [1]. The SNI mouse model involves ligation of two of the three branche...
متن کاملDevelopment of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block.
BACKGROUND The mechanisms responsible for initiation of persistent neuropathic pain after peripheral nerve injury are unclear. One hypothesis is that injury discharge and early ectopic discharges in injured nerves produce activity-dependent irreversible changes in the central nervous system. The aim of this study was to determine whether blockade of peripheral discharge by blocking nerve conduc...
متن کاملUpregulation of the GABA transporter GAT-1 in the gracile nucleus in the spared nerve injury model of neuropathic pain.
Neuropathic pain is a major health issue and is frequently accompanied by allodynia (painful sensations in response to normally non-painful stimulations), and unpleasant paresthesia/dysesthesia, pointing to alterations in sensory pathways normally dedicated to the processing of non-nociceptive information. Interestingly, mounting evidence indicate that central glial cells are key players in all...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Pain
سال: 2007
ISSN: 1744-8069,1744-8069
DOI: 10.1186/1744-8069-3-21